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Updated advice for healthcare professionals not to mix or infuse ceftriaxone with solutions containing calcium.
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Doses of theophylline, fluvoxamine, caffeine, coumarins including warfarin and the antipsychotics clozapine and olanzapine may have to be altered.
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The human papillomavirus (HPV) immunisation programme is now entering its second year and this article summarises the safety experience to date.
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The study found no clear evidence that varenicline was associated with an increased risk of fatal or non-fatal self-harm.
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Patients with existing meningioma or a history of meningioma must not be prescribed high-dose (鈮�25 mg per day) cyproterone acetate.
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The tighter controls being introduced to minimise risk of overuse and or addiction of painkillers containing codeine or dihydrocodeine.
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The European Medicines Agency has advised that no change in recommendations for use is required at present.
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How to reduce risk of illicit use.
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How MHRA monitors the impact of regulatory action taken.
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Important to inquire if patients are taking herbal medicines.
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Cold-chain storage and distribution system now been fully implemented by manufacturer.
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Use of has led to serious paracetamol overdose in a 6-month-old infant.
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Overall benefits of long-acting 尾-agonists (LABAs) in the treatment of chronic obstructive pulmonary disease (COPD) continue to outweigh any risks.
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Use during breastfeeding
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Healthcare professionals should consider a dose reduction or discontinuation of mycophenolate mofetil if patients develop pure red cell aplasia.
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Abacavir should be used in line with current treatment guidelines and with caution in patients with high cardiovascular risk factors.
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A reminder for those who use topical ketoprofen to avoid direct sunlight, ultraviolet rays, sunbeds or sunlamps.
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New safety information for intensive monitoring of Erlotinib.
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Topical oral salicylate gels are no longer indicated for people younger than 16 years for pain associated with infant teething, orthodontic devices, cold sores, or mouth ulcers.
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How pharmacists can prevent counterfeits reaching patients.
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Continued monitoring of medicines with a black triangle status.
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Use of Antipsychotic may be associated with an increased risk of venous thromboembolic events.
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These medicines are not first-line options for insomnia.
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You should take caution when you use NSAIDs in patients with renal impairment or are at risk.
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Use of aliskiren can cause angioedema, a rare and serious side effect, and or acute renal failure.
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Mothers who are breastfeeding should not take ACE inhibitors or angiotensin II receptor antagonists in the first few weeks after delivery.
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Data suggests that long-term use of carbamazepine, phenytoin, primidone, and sodium valproate is associated with decreased bone mineral density that may lead to osteopenia, osteoporosis, and increased fractures.
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High intravenous doses of methylthioninium chloride (methylene blue) should be avoided for patients being treated with serotonergic antidepressants (eg, SSRIs, clomipramine, and venlafaxine).
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Healthcare professionals may have more responsibility to accurately prescribe an unlicensed medicine or an off-label medicine than when they prescribe a medicine within the terms of its licence.
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Advice on how to use cough and cold medicines safely for children under 12 years.
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Updated guidance to use methylphenidateto safely and effectively for attention deficit hyperactivity disorder (ADHD) in children of 6 years or older and adolescents.
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Spontaneous reporting on the Yellow Card portal has provided important information in the identification of PML associated with some drugs.
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There have been reports of necrotising and haemorrhagic pancreatitis in people taking exenatide some of which were fatal - stop exenatide treatment if pancreatitis is diagnosed.
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Atomoxetine is associated with treatment-emergent psychotic or manic symptoms in children and adolescents - consider stopping this if symptoms occur.
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In 2008 MHRA commissioned Ipsos MORI to research the public鈥檚 perception of herbal medicines, the findings may help doctors and pharmacists when considering how to advise patients.
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Toremifene (fareston) is associated with a dose-dependent risk of QT prolongation.
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Generic piperacillin/tazobactam products have different compatibilities with other medicines compared with tazocin, raising a risk of serious medication errors.
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Severe infusion-related hypersensitivity reactions have occurred in patients receiving temsirolimus.
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The European Medicines Agency (EMA) has concluded that oral fluoroquinolone norfloxacin (Utinor) shouldn't be used to treat acute or chronic, complicated pyelonephritis.
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Toxic effects can occur with nitrous oxide especially with prolonged use.
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New warnings and contraindications for ergot-derived dopamine agonists due to risk of fibrosis associated with chronic use.
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Use the central alerting system to view and search new alerts, as well as past alerts that were issued through the public health link and safety alert broadcast system.
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MHRA has received reports of unintentional overdose of fentanyl due to dosing errors, accidental exposure, and exposure of the patch to a heat source.
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Patients with cancer who received recombinant human erythropoietins in clinical trials had an increased risk of tumour progression and reduced overall survival compared with study controls.
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Antiepileptic treatment is associated with a small risk of suicidal thoughts and behaviour.
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Do not prescribe etoricoxib to patients whose blood pressure is persistently above 140/90 mmHg and inadequately controlled.
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Clinical trial results suggest an increased risk of atrial fibrillation for zoledronic acid (Aclasta鈻�), pamidronic acid, and possibly for alendronic acid, although the balance-risk remains favourable for bisphosphonates.
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Licensed doses and differences in potency between different inhaled corticosteroids; advice for use with spacer device.
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Do not prescribe ergots to patients who have had fibrosis in the heart, lungs, or abdomen.
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Updated information on supply and clinical advice on enoxaparin (Clexane) pre-filled syringes, contaminated with over-sulphated-chondroitin sulphate (OSCS).